Detoxication mechanisms

the metabolism and detoxication of drugs, toxic substances and other organic compounds.
  • 796 Pages
  • 4.69 MB
  • English
Chapman and Hall
The Physical Object
ID Numbers
Open LibraryOL13656357M

The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals.

Biological Basis of Detoxication. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist Detoxication mechanisms book staff as they consider how to handle coronavirus.

Richard Tecwyn Williams FRS (20 February – 29 December ) was a Welsh biochemist who founded the systematic study of xenobiotic metabolism with the publication of his book Detoxication mechanisms in This seminal book built on his earlier work on the role of glucuronic acid in the metabolism of borneol.

He was born in Abertillery, Wales in and educated at the Gelli Crug Awards: Fellow of the Royal Society. Detoxication mechanisms;: The metabolism and detoxication of drugs, toxic substances, and other organic compounds [Williams, R.

Tecwyn] on *FREE* shipping on qualifying offers. Detoxication mechanisms;: The metabolism and detoxication of drugs, toxic substances, and other organic compoundsAuthor: R.

Tecwyn Williams. Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do.

This book is organized into three sections and comprised of 17 chapters. Detoxication Mechanisms. The Metabolism of Drugs and Allied Organic Compounds. Unknown Binding – See all formats and editions Hide other formats and editions. Price New from Used from Unknown Binding, "Please retry" Manufacturer: John Wiley & Sons.

In the s, metabolic studies on a broad range of compounds added considerably to the systemization of the metabolic routes of xenobiotics, culminating in publication of an expanded "Detoxication Mechanisms" in This book is still a marvel of organization and enlightenment.

The mechanisms by which thé body detoxi-cates certain harmful substances arising during the process of normal metabolism are well known, e.g., the formation of ethereal sulfates or of hippuric acid, but the subject has now widened to such an extent that it has come to include the study of the chemical changes undergone by all organic compounds in the body whether they give rise to toxic Cited by: Many of the reactions which foreign compounds undergo in the common laboratory animals are found to occur also in man.

There are exceptions to this, however, such as the glutamine coniugation of arylacetic acids, which occurs only in man and the chimpanzee and not in laboratory by: Detoxification Mechanisms in Insects. The first book in two decades to address this multi-faceted field, The Toxicology and Biochemistry of Insecticides provides the most up-to-date Author: Simon J.

The principal title of this book is misleading, since the bulk of the discussions relate to the metabolism of various drugs and chemicals. Furthermore, many of the reactions which drugs undergo in the body and which are classed as detoxication mechanisms actually result in the formation of substances more toxic than the parent compound.

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug.

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To survive the natural toxins, insects have evolved various detoxification mechanisms. These same mechanisms also sometimes allow insects to overcome insecticides, and the level and type of mechanisms differ greatly.

This results in differing toxicity among different stages, populations, and species of insects. Functional Medicine University’s Functional Diagnostic Medicine Training Program Module 6: FDMT A: The Physiology and Biochemistry of Biotransformation File Size: 2MB.

detoxication: [ de-tok″sĭ-fĭ-ka´shun ] 1. reduction of the toxic properties of a substance. treatment designed to assist in recovery from the toxic effects of a drug. metabolic detoxification reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or more readily.

Detoxication mechanisms; the metabolism and detoxication of drugs, toxic substances, and other organic compounds Williams, R. Tecwyn (Richard Tecwyn) QPW7   Detoxication Mechanisms.

The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic CompoundsAuthor: J. Barnes. “Phase I and Phase II” Drug Metabolism: Terminology that we Should Phase Out.

Article (PDF Available) in Drug Metabolism Reviews 37(4) February w Reads. This awareness has stimulated much research into the exposure, metabolism, and toxicity of chemical pollutants. This chapter discusses one aspect of the bodily defense against pollutant exposure—detoxication mechanisms, with particular emphasis on their relationship to by: 2.

Overview. Aims and Scope. The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents.

The scope includes effects on the organism at all stages of development. Detoxication Mechanisms Detoxication Mechanisms Quick, Armand J. Department of Pharmacology, Marquette University School of Medicine, Milwaukee, Wisconsin From the trend of the current biological literature, one can discern the beginning of a realization that the so�called detoxication mecha­ nisms are not isolated biochemical curiosities, but probably constitute.

Detoxication Mechanisms Detoxication Mechanisms Harrow, Benjamin; Sherwin, Carl P. Department of Chemistry, City College, College of the City of New York AND CARL P. SHERWIN 40 East 61st Street New York City This review confines itself. more or less, to the research work done during the last two years.

The earlier work has already been covered (1, 2). Clin Pharmacol Ther. Mar-Apr; Detoxication mechanisms in man.

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WILLIAMS RT. PMID: [PubMed - indexed for MEDLINE] MeSH TermsCited by:   The selenium (Se)-containing antioxidant selenoneine (2-selenyl-N α,N α,N α-trimethyl-l-histidine) has recently been discovered to be the predominant form of organic Se in tuna gh dietary intake of fish Se has been suggested to reduce methylmercury (MeHg) toxicity, the molecular mechanism of MeHg detoxification by Se has not yet been by: Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): g (external link)Author: Ethel Browning.

Excretion - Excretion - Regulation of water and salt balance: The mechanisms of detoxication that animals use are related to their modes of life.

This is true, with greater force, of the mechanisms of homeostasis, the ability of organisms to maintain internal stability. A desert-living mammal constantly faces the problem of water conservation; but a freshwater fish faces the problem of getting. The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents.

Purchase Biological Basis of Detoxication - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Europe PMC is an ELIXIR Core Data Resource Learn more >. Europe PMC is a service of the Europe PMC Funders' Group, in partnership with the European Bioinformatics Institute; and in cooperation with the National Center for Biotechnology Information at the U.S.

National Library of Medicine (NCBI/NLM).It includes content provided to the PMC International archive by participating publishers. Williams, in his classic book, Detoxication Mechanisms, suggests that the metabolism of many xenobiotics occurs in two steps [1].

The first, termed “phase I reactions,” includes oxidative, reductive, and hydrolytic reactions; the second, termed “phase II reactions,” consists of conjugative reactions and includes, for example Cited by:.

protective effects of total polysaccharides in compound kuqinin canine parvovirus infection and its influence on the expression of bax and bcl-2 gene based on .Preface.

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Introduction. Growth-Linked Biodegradation: Assimilation of Carbon; Assimilation of Other Elements. Acclimation: Factors Affecting Acclimation; Accelerated Pesticide Biodegradation; Explanations for the Acclimation Phase; Enzyme Induction and Lag Phase. Detoxication.

Activation: Mechanisms of activation; Defusing; Change in Toxicity Spectrum; Risks from Biodegradation.4/5(1).This is a discussion of selected topics which have appeared in the literature from to October It is limited to those studies in which the nature of the reaction is clearly defined, and the term " detoxication ", as used here, does not necessarily imply that a non-toxic or less toxic product has resulted from the changes undergone by the parent compound.